This is just a small post containing a few mods and tricks that can help removing crashes:

First go ahead and install this: http://nvse.silverlock.org/

Must haves:
1. NVAC - New Vegas Anti Crash (Link: http://www.nexusmods.com/newvegas/mods/53635/?)
2. New Vegas Stutter Remover (Link: http://www.nexusmods.com/newvegas/mods/34832/?)
3. 4GB launcher (Requires your system to have over 4GB RAM, Link: http://www.nexusmods.com/newvegas/mods/35262/?)

Fixing the fallout config file:
In your fallout installation folder there should be a file called "Fallout_default.ini" open it and go to the line that says "bUseThreadedAI=0" and change it to: "bUseThreadedAI=1"
also add the line "iNumHWThreads=4" if it isn't there already. This is the thread count that the game can access, I have a CPU with 8 threads and I found that beyond 4 it just gets crashy without any performance gains so I recommend you having it at 4 however make sure your CPU actually have the thread count you set it to.