So after playing around w/ DD mod family and Simple Slaves, I've come across this pretty much game breaking "glitch(?)". I can't interact/activate with any material at all.
I can talk to NPCs, I can fight. I cannot open doors, chest, pick up items, rogdoll, and I cannot sleep.
The intereaction that comes up when the crosshair is on said objects is "[E] Can't Do That".
Just by the wording of it I don't think it's a vanilla thing. It has got to be a mod, whether it's an intended