well if you can't run vanilla then I am wondering if your computer even meets the minimum required specifications to play the game.
My computer... well, let's just say the "recommended setting" for Skyrim is "Ultra". It far surpasses the recommended requirements. I think something it corrupt, a file, or maybe a mod or something, I don't know. I used to be able to play just fine, with the normal crashes here and there of course.
Well, all I can recommend is to thoroughly remove all traces of oblivion after uninstalling (remember that your oblivion folder will not be deleted with an uninstall if you have any mods) and try again.